Koyosamine HCL – Highly Purified Glucosamine Proven to Work!


Alpha-Wellness Koyosamine HCL is a patented, highly purified glucosamine from Japan that undergoes a proprietary refinery process from shells of Crustacea such as crabs and shrimps. Glucosamine is an amino sugar and belongs to the family of glycosaminoglycans, together with hyaluronic acid, chondroitin sulfate, keratin sulfate, heparin, etc, which contribute to the strength, softness and elasticity of connective tissues and cartilages.

Koyosamine HCL is a prominent building block and lubricant to cartilage and connective tissues to maintain proper-functioning joint structures. Clinical studies have proven the cartilage regeneration property of Koyosamine HCL in arthritic patients with its anti-inflammatory activity.

Besides supporting joint functions, Koyosamine HCL also promotes skin aesthetic effect and improvement in blood circulation.

Koyosamine HCL is manufactured in Japan with comprehensive quality program compliance to Food cGMP, ISO 9001 and FSSC 22000.



Do you know that conventional anti-inflammatory drugs used to treat joint pain such as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and COX -2 (Inflammatory markers) inhibitors may pose serious side-effects such as gastrointestinal problems and increased risk of heart attack?*

Koyosamine HCL has been proven to safely and effectively relieve joint discomfort without posing harmful side effects to the human body.

*Source: https://www.fda.gov/downloads/drugs/drugsafety/ucm088646.pdf

  • Provides strength to cartilage
  • Supports cartilage regeneration
  • Relieves joint inflammation and pain
  • Improves skin texture
  • Promotes good blood circulation
  1. Joint Care

a. The restorative effect of orally administered Koyosamine® HCL (1g/day) on rabbit’s cartilage was investigated. Rabbits with joint cartilage damage showed complete recovery after 3-week treatment with Koyosamine® HCL.koyosamine-chart2

(Tamai, Yasunori, et al. “Enhanced healing of cartilaginous injuries by glucosamine hydrochloride.” Carbohydrate Polymers 48.4 (2002): 369-378.)

b. A study on the effect of Koyosamine HCL on rat adjuvant arthritis, a model of rheumatoid arthritis, was conducted. A 300 mg/kg of Koyosamine HCL, an extra-dose compared with a regular dose for osteoarthritis patients (1.5 g/day, approximately 25 mg/kg), was orally administered once a day to the arthritic rats for 22 days. Koyosamine HCL significantly suppressed the increase in arthritis score after day 10 of adjuvant injection, and inhibited the swelling of arthritic joints after day 18. In addition, histopathological examination of the arthritic joints revealed that glucosamine suppressed synovial hyperplasia, cartilage destruction and inflammatory cell infiltration.

These observations suggest that Koyosamine HCL can suppress the progression of adjuvant arthritis in rats. Koyosamine HCL may be expected as a novel anti-inflammatory agent for treatment of rheumatoid arthritis.


(Hua, J., et al. “Preventive actions of a high dose of glucosamine on adjuvant arthritis in rats.” Inflammation Research 54.3 (2005): 127-132.)

c. Outpatients with knee osteoarthritis showed significant improvement in spontaneous pain, joint tenderness as well as walking ability after taking 1.0g & 1.5g a day Koyosamine® HCL for 8 weeks. (No. of subjects: 50)


(Kajimoto, O., et al. “Therapeutic activity of oral glucosamine hydrochloride in osteoarthritis of the knee: A placebocontrolled, double-blind, cross-over study.” Nippon Rinsho Eiyo Gakkaishi 20 (1998): 41-47.)

  1. Improved Blood Circulation

The anti-thrombotic action of Koyosamine HCL was evaluated. Human platelet-rich plasma was stimulated with 2.5 μM ADP in the presence of Koyosamine HCL (0.01 ~ 1 mM) or other aminosugars and platelet aggregation was monitored. The results showed that Koyosamine HCL effectively suppressed platelet aggregation and exhibited anti-thrombotic activities.

(Hua, J., et al. “Glucosamine, a naturally occurring amino monosaccharide, suppresses the ADP-mediated platelet activation in humans”. Inflammation Research 53.12 (2004): 680 – 688.)

  1. Skin Aesthetic Effect

Long-term intake of Koyosamine HCL (1500mg/day for 6 weeks) was conducted in women who usually tend to have dry and rough skin. Examination by dermatologists indicated that Koyosamine HCL significantly improved dryness of the skin, easiness to apply make-up, and exfoliation. Skin moisture content also increased. Moreover, microscopic skin surface analysis showed that Koyosamine HCL improved smoothness and scaliness of the skin.

(Kajimoto, Osami, Shiori Suguro, and Takeo Takahashi. “Clinical effects of glucosamine hydrochloride diet for dry skin.” Journal-Japanese Society of Food Science And Technology 48.5 (2001): 335-343.)