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PRODUCT FACTS:
Alpha-Wellness™ Liv-Care is a chewable tablet that contains a patented rice bran extract from Japan which is pure, non-chemical and non-toxic. The active component in rice bran extract, policosanol, has been clinically studied to protect liver against alcohol toxicity. Policosanol is a mixture of aliphatic alcohols of more than 20 carbons extracted from rice bran wax. Liv-Care is effective in relieving hangover discomfort. It also has the benefit in lowering low density lipoprotein, LDL (bad) cholesterol level.
Do You Suffer from Asian Flush?
Approximately 30 to 50% of Asian individuals have a genetic mutation in their alcohol metabolizing enzymes, especially aldehyde dehydrogenase 2 (ALDH2) found in the liver.
Alcohol is enzymatically broken down into a toxic intermediate product, acetaldehyde before its final non-toxic end-product, acetic acid. Alcohol flush and symptoms of hangover discomfort such as headache, nausea and drowsiness are caused by the accumulation of acetaldehyde in the body due to low activity of enzyme ALDH2.
How Does Liv – Care Relieve Hangover Discomfort?
Liv-Care promotes the conversion of acetaldehyde into non-toxic acetic acid by enhancing the enzymatic activity of ALDH2, thus relieving hangover discomfort.
Consumption of Liv-Care at 40 mg/day for 6 weeks led to significant reductions in acetaldehyde concentrations in eight healthy adult men. Blood acetaldehyde concentrations at 180 min after consumption of 25 g of ethanol were also decreased. Before policosanol supplementation, the mean acetaldehyde level (5 µmol/L) was 13.0 µmol/L, but none of the subjects had detectable acetaldehyde levels after the experiment. (No. of subjects: 8 male)
(Ohkubo, T., T. Ito, and H. Hibino. “Feasibility study on the use of policosanol to reduce blood acetaldehyde levels in ethanol-administered humans.” Journal of Japanese Society of Nutrition and Food Science 62.6 (2009): 305-309.)
A questionnaire on hangover effects was conducted on consumers who drank alcohol before and after 6-week intake of Liv-Care. All consumers reported feeling reduction of hangover discomfort upon taking Liv-Care.
(Source: Koyo Chemical Co. Ltd, Japan)
A group was healthy men (Age: 44.1±8.2) were orally administered with 20mg/day of Liv-Care for 28 days and their serum LDL-cholesterol level was measured. The results showed significant decrease of serum LDL-cholesterol.
(Source: Koyo Chemical Co. Ltd, Japan)
A human trial was conducted with oral administration of Liv-Care (33 mg/day) for a period of 6 weeks to measure the effect of Liv-Care on three types of liver disease markers: aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase (γ-GTP). AST or ALT is used to detect inflammation due to injury or damage to the liver by external factors such as drinking alcohol. γ-GTP is the indicator of alcoholic liver disease. The results showed significant decrease in all three liver disease markers at the end of the experiment, suggesting that Liv – Care helps to improve liver function.
(Source: Koyo Chemical Co. Ltd, Japan)
